Hemodialysis and Risk of Sudden Cardiac Death

Kemal Mağden; Nart Zafer Baytugan

doi:10.51645/khj.2025.500

Kemal Mağden^¹, Nart Zafer Baytugan^²

¹Department of Cardiology, Gebze Fatih State Hospital, Kocaeli, Türkiye
²Department of Nephrology, Gebze Fatih State Hospital, Kocaeli, Türkiye

Keywords: Arrhythmias; end-stage renal disease; hemodialysis; sudden cardiac death.

Abstract

Objectives: Chronic kidney disease (CKD) is a significant global health concern affecting millions of individuals worldwide. Cardiac arrhythmias are highly prevalent in CKD patients, with sudden cardiac death (SCD) representing a substantial cause of mortality, accounting for approximately 25% of all deaths in this patient group. Our hypothesis was that hemodialysis (HD) patients have an increased risk of cardiac arrhythmias and SCD.

Methods: This single-center observational study enrolled 219 participants: 109 patients undergoing HD and 110 in the control group. A 12-lead resting electrocardiogram (ECG) was performed before and after dialysis in all patients on HD and once in the control groups.

Results: The T peak-T end (Tp-e) interval duration (p=0.001), Tp-e/QT ratio (p=0.001), and Tp-e/corrected QT (QTc) ratio (p=0.001) were significantly higher in the HD patients than in the control group. There was no significant difference in Tp-e dispersion (p=0.806) between the groups. Correlation analysis revealed significant correlations between parathyroid hormone levels and the Tp-e interval (p=0.001), Tp-e/ QT ratio (p=0.017), Tp-e/QTc ratio (p=0.006), and QTc interval (p=0.020) in HD patients. QT, QTc, and Tp-e durations, as well as QT/QRS, QTc/QRS, Tp-e/QT, and Tp-e/QT ratios, were found to be higher in post-dialysis ECGs than in pre-dialysis ECGs.

Conclusion: The resting ECG findings were analyzed in patients with HD and a predisposition to arrhythmias, and SCD was identified in this cohort.

Cite This Article: Mağden K, Baytugan NZ. Hemodialysis and Risk of Sudden Cardiac Death. Koşuyolu Heart J 2025;28(2):47–53

BibTex	`@article{ kosuyolu_heart_j1947, doi = {10.51645/khj.2025.500}, author = {Kemal Mağden, Nart Zafer Baytugan}, title = {Hemodialysis and Risk of Sudden Cardiac Death}, journal = {Koşuyolu Heart J}, year = {2025}, volume = {28}, number = {2}, pages = {47-53}, publisher = {Kartal Koşuyolu High Specialization Training and Research Hospital} }`
RIS	`TY - JOUR AU - Kemal Mağden, Nart Zafer Baytugan PY - 2025 TI - Hemodialysis and Risk of Sudden Cardiac Death SP - 47 EP - 53 JO - Koşuyolu Heart Journal J2 - Koşuyolu Heart J VL - 28 IS - 2 PB - DO - 10.51645/khj.2025.500 ER -`
EndNote	`%0 Journal Article %A Kemal Mağden, Nart Zafer Baytugan %T Hemodialysis and Risk of Sudden Cardiac Death %J Koşuyolu Heart Journal %D 2025 %V 28 %N 2 %P 47-53 %R 10.51645/khj.2025.500`
APA	Kemal Mağden, Nart Zafer Baytugan (2025). Hemodialysis and Risk of Sudden Cardiac Death. Koşuyolu Heart Journal, 28(2), 47-53. doi:10.51645/khj.2025.500
MLA	Kemal Mağden, Nart Zafer Baytugan. "Hemodialysis and Risk of Sudden Cardiac Death" Koşuyolu Heart Journal, vol. 28, no. 2, 2025, pp. 47-53. doi:10.51645/khj.2025.500.
Chicago	Kemal Mağden, Nart Zafer Baytugan. "Hemodialysis and Risk of Sudden Cardiac Death" Koşuyolu Heart Journal 28, no. 2 (2025): 47-53. https://doi.org/10.51645/khj.2025.500.
AMA	Kemal Mağden, Nart Zafer Baytugan. Hemodialysis and Risk of Sudden Cardiac Death. Koşuyolu Heart J. 2025; 28(2): 47-53. doi:10.51645/khj.2025.500.
Vancouver	Kemal Mağden, Nart Zafer Baytugan. Hemodialysis and Risk of Sudden Cardiac Death. Koşuyolu Heart J. 2025; 28(2): 47-53. doi:10.51645/khj.2025.500

Hemodialysis and Risk of Sudden Cardiac Death

Abstract

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